I'm a Wyss Technology Development Fellow at the Wyss Institute (supervisor: George Church, Harvard Medical School). My research interests are centered in Synthetic Biology, and in Biological Technology development. My research is centered in creating new synthetic systems to enable science and medicine. My research could be divided in three blocks: translation of DNA diversity into small molecule diversity, genome refactoring to create safe microorganims, and radically edit mammalian genomes to change properties such as pathogen resistance, or interspecies tissue compatibility.
I was trained as an Organic Chemist and as a Technical Engineer in Telecommunications. As undergraduate, I participated in several research projects. In 2003, I did an internship as Analytical Chemist in a water treatment company in London. In 2005, I worked as Organic Chemist in the Spanish Research Council carrying out solid phase synthesis. After that, I did my first steps in Biotechnology. I spent 9 month as undergraduate in the biochemistry lab at IQS, where I developed an assay for anti-cancer drug screening and I expressed recombinant proteins. After graduation, my interest for integration of experimental and in silicoapproaches brought me to a PhD in Systems Biology.
I started my PhD research at EMBL, but after the first year, I moved to the Centre for Genomic Regulation together with my group, where we continued our research in M. pneumoniae. My PhD research was centered in the use of high throughput technologies such as tiling arrays and next generation sequencing to characterize M. pneumoniae'stranscriptome. We focused our efforts in understanding operon structure/dynamics and antisense transcription (Güell et al.). We also developed a protocol for strand-specific transcriptome mapping using Next Generation Sequencing (Vivancos et al.). I intensively participated in parallel projects related to Systems Biology and Mycoplasma pneumoniae (A deep look into metabolism, Yus et al.; Protein complexes, Kühner et al.). In my postdoctoral research in Luis Serrano's lab, I mainly worked in two areas. On one hand, we integrated transcriptomics with quantitative proteomics data in M. pneumoniae . On the other hand, we used next generation sequencing data to study transcription initiation in different prokaryotic organisms.